Peptide Category

Fat Loss &
Metabolic

From the GLP-1 revolution to mitochondrial-level metabolic reprogramming. Nine compounds spanning receptor agonists, GH fragments, NNMT inhibitors, and neurotransmitter modulators — every pathway that matters for body composition, ranked by mechanism and potency.

9
Peptide Profiles
2
Named Stacks
12
Blood Markers
Featured Stack: Metabolic Fat Loss Stack — Retatrutide + AOD-9604 + 5-Amino-1MQ
All Fat Loss & Metabolic Peptides
Retatrutide
LY3437943 · Triple GLP-1/GIP/GCGR Agonist
The most potent weight loss peptide ever studied. Triple receptor agonist producing up to 24% body weight reduction in clinical trials. A generational leap over semaglutide and tirzepatide.
24%
Max Loss
1x
Weekly
Phase 3
Trial
Triple AgonistMetabolic StackGLP-1 Class
Semaglutide
Wegovy · Ozempic · GLP-1 Receptor Agonist
The compound that launched the GLP-1 revolution. FDA-approved for weight management with 15–17% body weight loss. The most prescribed and studied weight loss peptide globally.
~17%
Weight Loss
1x
Weekly
FDA
Approved
GLP-1FDA ApprovedGold Standard
Tirzepatide
Zepbound · Mounjaro · GLP-1/GIP Dual Agonist
Dual GLP-1/GIP receptor agonist that outperforms semaglutide. FDA-approved with up to 26% weight loss at the highest dose. The current best-in-class approved option.
~26%
Max Loss
1x
Weekly
FDA
Approved
Dual AgonistFDA ApprovedGLP-1/GIP
CagriSema
Cagrilintide + Semaglutide · GLP-1/Amylin
Novo Nordisk's combination of semaglutide with cagrilintide (amylin analog). Dual satiety signaling through two distinct appetite pathways. Phase 3 data shows ~22.7% weight loss.
~23%
Weight Loss
1x
Weekly
Phase 3
Trial
GLP-1 + AmylinNovo Nordisk
Survodutide
BI 456906 · GLP-1/Glucagon Dual Agonist
Boehringer Ingelheim's dual GLP-1/glucagon agonist. The glucagon component drives hepatic fat oxidation — particularly promising for NASH/MASH and visceral fat reduction.
~19%
Weight Loss
1x
Weekly
Phase 3
Trial
GLP-1/GCGRNASH Target
AOD-9604
Advanced Obesity Drug · Modified GH Fragment
Modified GH fragment (176-191) that targets fat metabolism without affecting blood sugar, IGF-1, or GH side effects. TGA-approved in Australia. One of the cleanest fat loss compounds available.
300
mcg/day
SubQ
Fasted
TGA
Approved
GH FragmentMetabolic StackClean Profile
Fragment 176-191
HGH Frag · GH Fragment 176-191
The original unmodified GH fragment. Amino acids 176-191 of growth hormone — the specific region responsible for lipolytic activity. AOD-9604 is based on this sequence with added stability.
250–500
mcg/day
SubQ
Fasted
0
IGF-1 Impact
GH FragmentLipolysis
5-Amino-1MQ
NNMT Inhibitor · Oral Metabolic Compound
Oral NNMT inhibitor that boosts NAD+ levels and increases energy expenditure through a completely novel pathway. No injection required — works through a metabolic mechanism independent of GLP-1.
50–100
mg/day
Oral
No Needles
NAD+
Boosted
Metabolic StackNNMTOral
Tesofensine
NS2330 · Triple Reuptake Inhibitor
Triple monoamine reuptake inhibitor (serotonin, dopamine, norepinephrine) that suppresses appetite through central nervous system pathways. Originally developed for Alzheimer's and Parkinson's.
0.25–0.5
mg/day
Oral
Capsule
CNS
Mechanism
Appetite ControlOralNeurotransmitter
Featured Protocol Stack
The Metabolic Fat Loss Stack
Maximum metabolic coverage through three independent pathways. Retatrutide handles receptor-level appetite suppression and energy expenditure. AOD-9604 adds GH-fragment lipolysis. 5-Amino-1MQ boosts NAD+ through NNMT inhibition. Three mechanisms, zero overlap, compounding results.
🔥 Retatrutide — 1–12mg/week (titrate) 💉 AOD-9604 — 300mcg/day fasted 💊 5-Amino-1MQ — 50–100mg/day oral 📈 CJC-1295/Ipa — muscle preservation
GLP-1 Progression
The GLP-1 Ladder
The evidence-based progression through GLP-1 class compounds. Start with semaglutide (FDA-approved, most data). Step up to tirzepatide if plateauing (dual agonist, stronger). Retatrutide is the ceiling — triple agonist, investigational, maximum potency. Never combine GLP-1 compounds.
1️⃣ Semaglutide — ~15–17% (FDA approved) 2️⃣ Tirzepatide — ~20–26% (FDA approved) 3️⃣ Retatrutide — ~24% (Phase 3)
Go Deeper

Get the complete metabolic protocol.

Our free Protocol Guide includes the complete Metabolic Fat Loss Stack — titration schedules, GLP-1 ladder progression, non-GLP-1 alternatives, blood work panels, and tracking templates.

Free 50-page Protocol Guide
38 peptides · 7 protocols · dosing tables · blood work reference
38+
Peptides
7
Protocols
50
Pages
Free Instant Access
Unlock your protocols.
Research-backed peptide guides, dosing calculators, and weekly intel — used by biohackers worldwide.
50-Page Protocol Guide PDF
38 peptides, 7 protocol templates, dosing tables, blood work reference
The Protocol Brief Weekly
Weekly research breakdowns, protocol spotlights, blood work insights
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