Peptide Category

Cognitive
Enhancement

Nootropic peptides that enhance focus, memory, neuroprotection, and neuroplasticity. From Russian-approved anxiolytics to the most potent synaptogenesis compounds ever studied — these are the molecules that upgrade your brain's hardware, not just its chemistry.

5
Peptide Profiles
2
Named Stacks
6
Blood Markers
Featured Stack: Limitless / Brain Stack — Semax + Selank
All Cognitive Peptides
Selank
TP-7 · Anxiolytic Nootropic
Synthetic tuftsin analog providing benzodiazepine-level anxiolysis without sedation or dependence. Modulates GABA, serotonin, and dopamine while enhancing BDNF expression. Approved in Russia.
200–600
mcg/day
Nasal
Route
RU
Approved
Brain StackGABABDNF
Semax
ACTH 4-10 Analog · Cognitive Enhancer
ACTH-derived peptide that robustly upregulates BDNF and NGF for neuroplasticity and memory. Approved in Russia for stroke recovery and cognitive enhancement. One of the most validated nootropic peptides.
200–600
mcg/day
Nasal
Route
BDNF
Booster
Brain StackNGFRU Approved
PE-22-28
Spadin Analog · Sigma-1 Agonist
Sortilin-derived peptide that blocks TREK-1 potassium channels for rapid antidepressant-like effects. Enhances serotonergic neurotransmission through a novel mechanism — faster onset than SSRIs.
100–500
mcg/day
SubQ
Route
Rapid
Onset
TREK-1SerotoninNovel
Dihexa
Angiotensin IV Analog · Extreme Nootropic
Reportedly 10 million times more potent than BDNF at forming new synaptic connections. Crosses the blood-brain barrier orally. The most powerful nootropic peptide studied — extremely limited human data.
10–40
mg/day
Oral
BBB Cross
10⁷x
BDNF Potency
SynaptogenesisOralExtreme
P21
CNTF Peptide · Neurogenesis
CNTF-derived peptide that promotes the growth of new neurons in the hippocampal dentate gyrus — the brain region critical for memory formation and spatial learning. True neurogenesis in adult brains.
50–100
mcg/day
SubQ
Nasal
Dentate
Gyrus
NeurogenesisCNTFMemory
The Gold Standard
The Limitless Stack
Semax for BDNF/NGF upregulation and cognitive enhancement paired with Selank for anxiolysis and emotional stability. The Russian-developed combination that addresses both cognitive performance and stress resilience without sedation or dependence.
🧠 Semax — 200–600mcg/day intranasal 😌 Selank — 200–600mcg/day intranasal 💉 BPC-157 — neuroprotective support (optional)
Advanced Neurogenesis
The Deep Brain Protocol
For experienced users pursuing maximum neuroplasticity. Dihexa drives synaptogenesis at extreme potency while P21 promotes actual neurogenesis in the hippocampus. Semax provides the BDNF foundation. Extremely limited human data — proceed with caution and medical guidance.
⚡ Dihexa — 10–40mg/day oral 🔬 P21 — 50–100mcg/day 📈 Semax — BDNF foundation
Go Deeper

Get the complete cognitive optimization protocol.

Our free Protocol Guide includes complete Cognitive protocols — dosing schedules, stacking recommendations, blood work panels, and tracking templates.

Free 50-page Protocol Guide
38 peptides · 7 protocols · dosing tables · blood work reference
38+
Peptides
7
Protocols
50
Pages
Free Instant Access
Unlock your protocols.
Research-backed peptide guides, dosing calculators, and weekly intel — used by biohackers worldwide.
50-Page Protocol Guide PDF
38 peptides, 7 protocol templates, dosing tables, blood work reference
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Weekly research breakdowns, protocol spotlights, blood work insights
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